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Zithromax is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, skin infections, ear infections, and sexually transmitted diseases. Zithromax Azithromycin fights bacteria in the body. Zithromax (Azithromycin) is a macrolide antibiotic used to treat bacterial infections. It is prescribed for adults to treat certain mild to moderate skin infections; upper and lower respiratory tract infections, including pharyngitis (strep throat), tonsillitis, sinus infections, worsening of chronic obstructive pulmonary disease, and pneumonia; sexually transmitted infections of the cervix or urinary tract; and genital ulcer disease in men.